Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children

The endocrine and nervous systems reciprocally interact to manage physiological individual functions homeostasis. system modulates hormone release through the hypothalamus, main cerebrally specialized structure of neuroendocrine system. hypothalamus is involved in various metabolic processes, administering neuropeptide at different levels. This complex activity affected by neurons cerebral areas, environmental factors, peripheral organs, mediators feedback mechanisms. Therefore, pathways play a key role homeostasis control, their abnormalities are associated with development syndrome (MetS) children. impaired functioning genes, hormones, neuropeptides several processes related an increased risk dyslipidaemia, visceral obesity, insulin resistance, type 2 diabetes mellitus, hypertension. review examines effects on MetS children, identifying underlying conditions pathway disruption. Neuroendocrine should be considered pathophysiology MetS, and, when genetic or epigenetic mutations “hot” occur, they could studied for new potential target therapies severe drug-resistant paediatric forms MetS.